Thymosin Beta-4 Fragment (1-4) (Ac-SDKP) 1,000mcg – Capsules

Ac‑SDKP (N‑acetyl‑Ser‑Asp‑Lys‑Pro) is a naturally occurring tetrapeptide derived from the N‑terminal region of Thymosin β4 and composed of four amino acids. It is widely used in pre‑clinical research models to investigate anti‑fibrotic, anti‑inflammatory, and pro‑angiogenic mechanisms at the tissue level.

Research focus

Experimental work has shown that Ac‑SDKP can modulate signaling pathways such as TGF‑β and MEK‑ERK, which are central to fibroblast activation, extracellular matrix deposition, and inflammatory cell recruitment. In various organ systems, it is studied for its ability to limit pathological collagen accumulation and inflammatory infiltration in models of cardiac, renal, hepatic, pulmonary, and intestinal fibrosis.

Experimental findings

Animal studies indicate that Ac‑SDKP may help reverse established fibrosis, including reductions in ventricular collagen content in hypertensive rodent hearts. It has also been examined for effects on oxidative stress via influences on NADPH oxidase activity, as well as for dampening macrophage activation, TNF‑α production, and excessive collagen synthesis, all of which support its role as a tissue‑protective research peptide.

Formulation and use

In encapsulated form, Ac‑SDKP is provided as a stable, precisely dosed preparation suitable for long‑term studies in non‑human models. This format simplifies handling and storage, supports consistent systemic exposure, and reduces the need for complex solution preparation when investigating chronic tissue remodeling, fibrosis modulation, or inflammatory pathways.

Key characteristics

• Chemical sequence: Acetyl‑Ser‑Asp‑Lys‑Pro (Ac‑SDKP).

• CAS number: 120081‑14‑3.

• Molecular formula: C20H33N5O9.

• Molecular weight: approximately 487.51 g/mol.

• Common research names: Ac‑SDKP, N‑acetyl‑Ser‑Asp‑Lys‑Pro, Thymosin Beta‑4 Fragment 1‑4.

Legal disclaimer

This compound is supplied solely for research purposes and is not intended as a dietary supplement, medication, or for any form of human or veterinary consumption. It should be handled only by appropriately trained personnel using suitable laboratory facilities, protective equipment, and safety procedures, and such users assume full responsibility for storage, handling, and experimental application. Any descriptive information provided is for scientific and educational purposes only, has not been evaluated by regulatory authorities, and is not intended to diagnose, treat, cure, or prevent any disease.